-, Alber F, et al. Here are just a few examples. Hirano Y, Asakawa H, Sakuno T, Haraguchi T, Hiraoka Y. In section 3, the inner ring region is indicated by “spokes”. Key NPC architectural features and principles, (A) Severity of fitness defects, indicated in…, Figure 6. Nuclear pore complexes play central roles as gatekeepers of RNA and protein transport between the cytoplasm and nucleoplasm. Molecular details of Nup arrangement are shown at bottom (relevant residue numbers indicated). Scale bar 100 Å. The Integrative Anatomy group at MU is a core of faculty, post-doctoral researchers, and graduate students within the Department of Pathology and Anatomical Sciences at the University of Missouri School of Medicine whose research bridges fields of evolutionary morphology and clinically relevant anatomical sciences. Identity of mapped Nups is shown in the diagram on the right. Resolution estimates for the Cryo-ET map of the NPC and comparison…, Extended Data Figure 6. This emphasis on whole-body function, and its applications to human health and disease, has made Integrative Physiology the … Small cartoon insets of the NPC are used to illustrate the analysis. 1989;109:955–970. doi: 10.1016/j.ceb.2014.02.001. Comparison of the S. cerevisiae NPC structure and human NPC core…, Extended Data Figure 11. Proposed evolutionary origin of the NPC from a later amalgam of…, Extended Data Figure 12. The anchoring points of the coiled-coil cytoplasmic Nup82 complex and the nuclear basket (orange densities) into an equivalent region of the outer ring Nup84 complex (grey density) are shown. A diagram indicates convex and concave pore membrane curvatures. (Bottom) Another duplication and divergence within each spoke may then have generated two parallel and laterally-offset paralogous columns; in the outer ring, a COPII-like subunit was then lost from one of the duplicates. (B) Diagonally oriented columns reinforcing the core scaffold may accommodate NPC compression and expansion (diagram to right). Sampathkumar P, Kim SJ, Upla P, Rice WJ, Phillips J, Timney BL, Pieper U, Bonanno JB, Fernandez-Martinez J, Hakhverdyan Z, Ketaren NE, Matsui T, Weiss TM, Stokes DL, Sauder JM, Burley SK, Sali A, Rout MP, Almo SC. (B–C) Structures corresponding to the position of the most severe defects (dark blue). Strains for which truncations in a haploid background were found to lead to lethality after tetrad dissection (Nic96 and Nup192) were assigned the maximum level of defect and plotted on top of the rest (diploid), based on the fitness phenotype observed for the indicated Nic96 and Nup192 mutants in a diploid background (where a wild type copy of the nucleoporin is also present and expressed). Mol Cell Proteomics. See what our recent graduates have done on the Career Center website. Types of cross-links are indicated in the top left diagram. Nuclear Envelope Proteins Modulating the Heterochromatin Formation and Functions in Fission Yeast.
Comparison of the…, Extended Data Figure 10. After all, I feel like more and more doctors are discovering that disease can be caused and aggravated by our lifestyles over time rather than by one event. Quantitative analysis of…, Extended Data Figure 2. What Are the Advantages of the Integrative Approach. Middle, the initial duplication leading to the origin of the inner and outer rings and their associated coiled bundles. Scale bar 100 Å. Structural characterization by cross-linking reveals the detailed architecture of a coatomer-related heptameric module from the nuclear pore complex. At bottom, the integration of the different data points into a final comprehensive description of the endogenous assembly is depicted.
@indigomoth - It's also just good practice for anyone who is actually going to work on the ground with people, rather than doing research, to be holistic rather than completely specialized. -, Stanley GJ, Fassati A, Hoogenboom BW. doi: 10.1083/jcb.109.3.955. COVID-19 is an emerging, rapidly evolving situation. Biomechanics of the transport barrier in the nuclear pore complex. NIH Top and bottom, molecular details of spoke-to-spoke connector hinges. Second row right, one spoke in side view, showing how horizontal connector Nups (aquamarine) connect modules spanning from the pore membrane to the central channel. (B) Conserved structural motifs connecting spokes in the outer and inner rings. A remnant of the pore membrane is present (M), encircling the entire mid-line of the NPC. Chemical cross-linking and mass spectrometry reveals nucleoporin connectivity in the NPC, (A–B) Cryo-ET map of the NPC: core scaffold, blue;…, Figure 4. Welcome.
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